Clinical case of systemic sclerosis in the course of lung adenocarcinoma

We present a patient with 5 years systemic sclerosis diffuse scin manifestations, capillaroscopic data to confirm diagnosis, elevated levels of ANA-antibodys, Anti-Sox-1, Anti-Ro-52 and Anti-Histoni in the course lung adenocarcinoma (proven by fibrobronchoscopy biopsy) brain metastasis consequence. From clinical examination it is established weakened vesicular respiration right site lung, astheno-adynamic syndrome, shortness breath usual physical exertion. function testsр FVC 58% anf FEV1 59%. The on wide area half not indicated for surgical treatment. Patient was conducted 4 cours chеmotherapy Alimta + Cisplatin from marth 2016 г jull year, 7 Docetaxel februari 2017 year septembre radiotherapy. One later complaints appear forget words, hard reading writing. Computed tomography (CT) shows intracranial tumor formation heterogeneous structure left frontal btain – methastasis after adenocarcinoma. Was operative removal tumoral formation, postoperative radiotherapy Depakin chrono 2 time 500 мг daily. treatment followed 8 mg Methylprednisolon 250 Cuprenil good therapeutic effect.